So I have been on PIO now for 3 weeks and its making my butt itch so bad!!! I did not have this reaction last time I was on it. It itches so bad that my skin gets super raw and it hurts. I dont know if its just how I am reacting to it. I am going to deal with it cause I have to but I have to try so hard to not scratch. Just another fun side effect!!! I also think its making me hot and not the irresistible type either, lol. It feels like I am boiling and I know its summer but to be in AC and still be hot is out of control. Venting done!!! Its 10000% worth it to hopefully bring home our baby!!!